Antibiotic resistance pattern of Klebsiella pneumoniae isolated from nosocomial infections in Aleshtar hospital, Lorestan province

Report of Health Care

مقاله 3، دوره 1، شماره 2، خرداد 2015، صفحه 55-59   

نوع مقاله: Original Article

نویسندگان

Sajad Babakhani^{* 1}؛ Shahram Shokri²؛ Mahdieh Baharvand³

¹MSc of Microbiology, Department of Biology, Islamic Azad University, Ashkezar Branch, Ashkezar, Iran

²Assistant Professor, Infectious Diseases Specialist, Lorestan University of Medical Sciences, Khorramabad, Iran

³MSc of Microbiology, Department of Biology, Islamic Azad University, Borujerd Branch, Borujerd, Iran

تاریخ دریافت: 12 خرداد 1394،  تاریخ بازنگری: 15 فروردین 1394،  تاریخ پذیرش: 25 فروردین 1394 

چکیده

Introduction: Klebsiella pneumoniae is one of Klebsiella species. K. pneumoniae is one of the most important bacteria causing nosocomial infections. This bacterium threatens public health and leads to increased hospital costs and mortality rate. The purpose of this study was to determine the pattern of antibiotic resistance in K. pneumoniae in nosocomial infections.
Methods: This study was performed on 51 samples of Klebsiella isolates from 500 patients in three units of Aleshtar hospital in 9 months. The antibiotic resistance of K. pneumoniae to 18 antibiotics was performed by Kirby Bauer disk diffusion method.
Results: The frequency of K. pneumonia among 500 samples was determined 51 cases (10.2%). The largest number of K. pneumoniae was isolated from the infectious unit (49.02%). The frequency of K. pneumoniae based on the source of infection for urine was 22 cases (43.14%), sputum 17 (33.33%), stool 6 (11.77%), wound 4 (7.84%), blood 2 (3.92%), and cerebrospinal fluid 0 (0%), respectively. K. pneumoniae resistance to antibiotics included: ceftriaxone (94.12%), ciprofloxacin (90.20%), ofloxacin (86.27%), cefotaxime (78.43%), nalidixic acid (58.82%), nitrofurantoin (56.86%), aztreonam (54.90%), ampicillin/sulbactam (50.98% ), ticarcillin (45.09%), cefepime (43.14%), colistin (43.14%), gentamicin (41.18%), azithromycin (41.18%), polymyxin B (39.22%), piperacillin/tazobactam (19.61%), amikacin ( 15.69%), imipenem (5.88%), and meropenem (3.92%).
Conclusion: Meropenem and imipenem with the lowest resistance were the most effective antibiotics against K .pneumoniae. Ceftriaxone, and ciprofloxacin antibiotic had the lowest effect on the treatment of K. pneumoniae.

کلیدواژه‌ها

Klebsiella pneumoniae؛ Antibiotic resistance؛ Nosocomial infections

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