Lipid Lowering Effects of Aqueous Saffron Extract in Diabetic Rats

Report of Health Care

مقاله 2، دوره 2، شماره 3، مهر 2016، صفحه 9-114   

نویسندگان

Elham Adibfar¹؛ Seyed Ali Hoseini¹؛ Omidreza Salehi¹؛ Fatemeh Farkhaie¹؛ Parvin Shah Hosseini²

¹Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran

²Doctor of Veterinary Medicine

تاریخ دریافت: 23 بهمن 1394،  تاریخ بازنگری: 16 خرداد 1395،  تاریخ پذیرش: 02 تیر 1395 

چکیده

Introduction: Diabetes mellitus is one of the most common non-communicable and chronic diseases. The present study aimed to review the lipid lowering effects of aqueous saffron extract in diabetic rats. Methods: Sixty diabetic rats with fasting blood glucose of over 300 mg/dl were selected as sample and divided in two groups of saffron extract and control. Group of saffron extract received 25 mg/kg daily aqueous saffron extract peritoneally for 4 weeks. Lipid profile was measured by enzymatic method with zist shimi commercial kits provided by yasa teb Company. For statistical analysis of data, Kalmogorov- Smirnov test and paired sample and independent sample t- tests (p≤0.05) were used. Results: Findings showed that 4 weeks saffron extract induces significant reduction in LDL, VLDL, TG and Cho of diabetic rats (p=0.001); nevertheless, it has no significant effect on HDL (p=0.07). Conclusion: It is concluded that 4 weeks aqueous saffron extract has lipid lowering effect in diabetic rats.

کلیدواژه‌ها

Saffron؛ Lipid Profile؛ Diabetes

مراجع

1. Askari M, Hoseini SA. Effect of hydroalcoholic extracts of anethum graveolens L. with swimming training on lipid profile of diabetic rats. Horizon Med Sci J. 2016; 22 (4): 345- 351.

2. Farsi S, Azarbayjani MA, Hosseini SA, Piree M. Response of serum levels of ICAM-1, VCAM- 1 and CRP to high and moderate endurance trainings in sprague dawley male diabetic rats. Armaghane Danesh J. 2016; 21 (8): 18- 25.

3. Zar A, Hoseini SA, Ahmadi F, Rezaei M. Effects of ginger with swimming training on blood fat profiles in adult diabetic rats with streptozotocin. Iranian J Nutr Sci Food Technol. 2016; 11 (2): 65- 74.

4. Hosseini SA, Nikbakht H, Azarbayjani MA. The effect of aqua extract of saffron with resistance training on glycemic indexes of streptozotocin induced diabetic tats. Armaghane Danesh J. 2014; 18 (4): 284- 294.

5. Mohajeri D, Mousavi G, Doustar Y. Antihyperglycemic and pancreas-protective effects of crocus sativus L. (Saffron) stigma ethanolic extract on rat with alloxan-induced diabetes. J Biol Sci. 2009; 9 (4): 302- 310.

6. Meamarbashi A, Hakimi V. Effects of saffron supplementation on the cardio-respiratory endurance in the healthy inactive girls. Saffron Agronomy Tech. 2014; 2 (3): 225- 230.

7. Samarghandian S, Borji A, Delkhosh MB, Samin F. Safranal treatment improves hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats. J Pharm Pharm Sci. 2013; 16: 352- 362.

8. Arasteh A, Aliyev A, Khamnei S, Delazar A, Mesgari M, Mehmamnavaz Y. Effects of hydromethanolic extract of saffron (Crocus Sativus) on serum glucose, insulin and cholesterol levels in healthy male rats. J Med Plants Res. 2010; 4: 397- 402.

9. Naderi GH, Asgari S, Zaher M, Babak S. The antioxidant effect of turmeric and saffron on oxidation of hepatic cells, LDL and HbA1c. J Med Plants. 2005; 4 (16): 29- 35.

10. Elgazar FA, Rezq AA, Bukhari MH. Anti- hyperglycemic effect of saffron extract in alloxan- induced diabetic rats. Eur J Biol Sci. 2013; 5: 14- 22.

11. Samarghandian S, Azimi- Nezhad M, Samini F. Ameliorative effect of saffron aqueous extract on hyperglycemia, hyperlipidemia, and oxidative stress on

diabetic encephalopathy in streptozotocin induced experimental diabetes mellitus. Bio Res Int J. 2014; 4: 1- 12.

12. Samadi H, Javadi S, Asri S. Evaluation of the effects of crocin on the serum levels of glucose, insulin, urea, ceratinine and Β2M in healthy and streptozotocin- induced diabetic rats. Urmia Med Sci J. 2015; 26 (9): 802- 812.

13. Yang L, Qian Z, Ji H, Yang R, Wang Y, Xi L. Inhibitory effect on protein kinase Cθ by crocetin attenuates palmitate-induced insulin insensitivity in 3T3-L1 adipocytes. Eur J Pharm. 2010; 642 (1-3): 47- 55.

14. Shirali S, Bathaei SA, Nakhjavani M, Ashoori MR. Effects of saffron (Crocus Sativus L) aqeous extract on serum biochemical factors in streptozotocin induced diabetic rats. Iranian J Med Aromatic Plants. 2012; 28 (2): 293- 308.

15. Xi L, Qian Z, Xu G, Zheng S, Sun S, Wen N. Beneficial impact of crocetin, a carotenoid from saffron on insulin sensitivity in fructose-fed rats. J Nutr Biochem. 2007; 18: 64- 72.

16. Milajerdi A, Mahmoudi M. Review on the effects of saffron extract and its constituents on factors related to nervous system, cardiovascular and gastrointestinal diseases. J Clin Excellence. 2014; 3 (1): 108- 127.

17. Xi L, Qian ZY, Shen XC, Wen N, Zhang YB. Crocetin prevents dexamethasoneinduced insulin resistance in rats. Planta Med J. 2005; 71 (10): 917- 922.

18. Rezaee Khorasany AR, Hosseinzadeh H. Therapeutic effects of saffron (Crocus Sativus L.) in digestive disorders: A review. Iranian J Basic Med Sci. 2016; 19: 455- 469.

19. Kianbakht S. A systematic review on pharmacology of saffron and its active constituents. Med Plants J. 2008; 4 (28): 1- 27.

20. Mashmoul M, Azlan A, Mohd Yusof B, Khaza’ai H, Mohtarrudin N, Taher Boroushaki M. Effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet. J Func Foods. 2014; 8: 180- 187.

21. Sahraian A, Jelodar S, Javid Z, Mowla A, Ahmadzadeh L. Study the effects of saffron on depression and lipid profiles: A double blind comparative study. Asian J Psychiatry. 2015; 807: 1- 3.

22. Nikbakht-Jama I, Khademib M, Nosratia M, Eslamic S, Foroutan-Tanhac M, Sahebkara et al, Effect of crocin extracted from saffron on pro-oxidant–anti-oxidant balance in subjects with metabolic syndrome: A randomized, placebo- controlled clinical trial. Eur J Integrative

Med. 2016; 8 (3): 307- 312.

23. Sheng L, Qian Z, Zheng S, Xi L. Mechanism of hypolipidemic effect of crocin in rats: crocin inhibits pancreatic lipase. Eur J Pharm. 2006; 543 (1): 116- 122.

24. Xi L, Qian Z, Xu G, Zhou C, Sun S. Crocetin attenuates palmitate-induced insulin insensitivity and disordered tumor necrosis factor-a and adiponectin expression in rat adipocytes. British J Pharm. 2007; 151: 610- 617.

25. Kang C, Lee H, Jung ES, Seyedian R, Jo M, Kim J. Saffron (Crocus Sativus L.) increases glucose uptake and insulin sensitivity in muscle cells via multipathway mechanisms. Food Chem. 2012; 135 (4): 2350- 2358.