The effect of rs7008740 and rs11987254 polymorphisms in MYBL1 gene and its effect on male infertility in Fars province-Iran

Report of Health Care

مقاله 2، دوره 6، شماره 1، خرداد 2020، صفحه 14-21

نوع مقاله: Original Article

نویسنده

heydar aqababa^*

Biology Department of Islamic Azad University, Arsanjan Branch

تاریخ دریافت: 16 اردیبهشت 1399،  تاریخ پذیرش: 26 خرداد 1399 

چکیده

Introduction: Infertility is defined by the failure to reach a clinical pregnancy after one year of unprotected sexual intercourse, and often 15% of couples are infertile. Male factor solely and partially contributes to about 20% and 50% of infertilities, respectively. Both environmental and genetic factors play important roles in infertility, and the mybl1 gene and its polymorphisms are well known in this case. This study was going to evaluate whether rs7008740 and rs11987254 polymorphisms in mybl1 gene have a significant relationship with the risk of male infertility in Fars province or not.
Materials and methods: This study involved 100 infertile men and 100 fertile men (control group). The Tetra-ARMS PCR and ARMS PCR techniques were used to detect mybl1 polymorphism genotypes.
Results: The results showed that rs7008740 and rs11987254 polymorphisms in mybl1 gene did not have a significant relationship with the risk of male infertility in this population (P>0.05). However, there was a significant relationship between family history and infertility (P <0.001).
Conclusion: This study indicated that rs7008740 and rs11987254 polymorphic loci in mybl1 gene did not have a significant relationship with the risk of male infertility.

کلیدواژه‌ها

Men Infertility؛ mybl1 gene؛ Polymorphism